| The potential thrombogenic action of a nonionic radiographic contrast medium used during coronary angiography is offset by heparin during coronary angioplasty. | |
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MedLine Citation:
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PMID: 8950772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iohexol sodium, a nonionic radiographic contrast medium, used in invasive imaging techniques has been shown to be potentially thrombogenic. In the present study, the effect of iohexol sodium on haemostatic factors was evaluated in 20 patients, 16 male and 4 female, 10 undergoing coronary angiography and another 10 undergoing coronary angioplasty. All the patients had angiographically-assessed coronary artery disease. The patients undergoing coronary angioplasty received a significantly larger quantity of the dye as compared with the patients undergoing coronary angiography. The former group of patients also received a bolus of 20,000 units of standard heparin in addition. The levels of thrombin-antithrombin-III complex (TAT), prothrombin fragments 1 and 2 (F1F2), D-dimer and the functional activity of tissue factor pathway inhibitor (TFPI) were assayed. While the baseline and 30-min post-dye levels of TAT and F1F2 were comparable in patients undergoing coronary angioplasty, the 30 min levels were significantly elevated in patients undergoing coronary angiography. The post-dye levels of TFPI activity were significantly increased in the former group due to the heparin-induced release of TFPI. It is concluded that the thrombogenic potential of iohexol sodium was overcome by heparin used routinely during coronary angioplasty. |
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Authors:
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M Mukherjee; M F Scully; M Thomas; D Jewitt; V V Kakkar |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 76 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-24 Completed Date: 1997-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 679-81 Citation Subset: IM |
Affiliation:
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Thrombosis Research Institute, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Antithrombin III / analysis Contrast Media / adverse effects* Coronary Angiography* Female Fibrin Fibrinogen Degradation Products / analysis Heparin / pharmacology, therapeutic use* Humans Iohexol / adverse effects* Lipoproteins / analysis Male Peptide Fragments / analysis Peptide Hydrolases / analysis Prothrombin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Fibrin Fibrinogen Degradation Products; 0/Lipoproteins; 0/Peptide Fragments; 0/antithrombin III-protease complex; 0/fibrin fragment D; 0/lipoprotein-associated coagulation inhibitor; 0/prothrombin fragment 1.2; 66108-95-0/Iohexol; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; 9005-49-6/Heparin; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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