Document Detail

The potential role of sphingolipid-mediated cell signaling in the interaction between hyperglycemia, acute myocardial infarction and heart failure.
MedLine Citation:
PMID:  22762510     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Patients with acute myocardial infarction or heart failure frequently have abnormalities of glucose metabolism and insulin resistance, both of which are associated with a poor outcome. Sphingolipids are a class of lipids, which play important roles in cellular biological processes including insulin resistance and myocardial ischemia.
AREAS COVERED: This review examines the available evidence linking abnormalities in sphingolipids, glucose tolerance and insulin resistance to acute myocardial infarction and heart failure.
EXPERT OPINION: Pharmacological and genetic activation of enzymes controlling key sphingolipids synthesis, such as sphingosine-1-phosphate, increases insulin sensitivity in rodents and increases myocardial tolerance to ischemia. Major projects are being realized to develop clinical strategies to manipulate sphingolipid metabolism in this clinical settings, with the ultimate goal of increasing insulin sensitivity and augmenting myocardial tolerance to ischemia. Thus, a clear understanding of the sphingolipid-mediated signaling in ischemic heart disease is required to devise strategies to develop novel agents and technologies that directly target this signaling pathway.
Emmanuel E A Egom; Mamas A Mamas; Andrew L Clark
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-05
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  16     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-12-04     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  791-800     Citation Subset:  IM    
University of Hull, Hull and East Yorkshire Hospitals NHS Trust, Academic Cardiology, Hull, East Yorkshire HU16 5JQ, UK.
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MeSH Terms
Cardiovascular Diseases / metabolism*
Glucose / metabolism
Hyperglycemia / metabolism*
Insulin Resistance
Signal Transduction
Sphingolipids / metabolism*
Reg. No./Substance:
0/Sphingolipids; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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