| The potential role of the red blood cell in nitrite-dependent regulation of blood flow. | |
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MedLine Citation:
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PMID: 20952416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrite was once thought to have little physiological relevance. However, nitrite is now being increasingly recognized as a therapeutic or possibly even physiological precursor of nitric oxide (NO) that is utilized when needed to increase blood flow. It is likely that different mechanisms for nitrite bioconversion occur in different tissues, but in the vascular system, there is evidence that erythrocyte haemoglobin (Hb) is responsible for the oxygen-dependent reduction of nitrite to modulate blood flow. Here, we review the complex chemical interactions of Hb and nitrite and discuss evidence supporting its role in vasodilation. We also discuss ongoing work focused on defining the precise mechanisms for export of NO activity from red blood cells and of other pathways that may mediate nitrite-dependent vasodilation. |
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Authors:
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Rakesh P Patel; Neil Hogg; Daniel B Kim-Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-14 |
Journal Detail:
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Title: Cardiovascular research Volume: 89 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-04-28 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 507-15 Citation Subset: IM |
Affiliation:
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Department of Pathology and Center for Free Radical Biology, University of Alabama, Birmingham, AL 35294, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Erythrocytes / metabolism* Humans Nitrites / metabolism* Regional Blood Flow / physiology* Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM55792/GM/NIGMS NIH HHS; HL090503/HL/NHLBI NIH HHS; HL092624/HL/NHLBI NIH HHS; HL58091/HL/NHLBI NIH HHS; R37 HL058091-15/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrites |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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