Document Detail

A potential role for prolactin in zinc homeostasis.
MedLine Citation:
PMID:  3357456     Owner:  NLM     Status:  MEDLINE    
Zinc is an important trace metal co-factor for many metallo-enzymes and may have a critical role in the stabilization and function of biomembranes. Zinc-depleted animals increase their fractional absorption of zinc to restore zinc homeostasis. This increase in fractional absorption is not currently known to be hormonally-mediated. Recently, zinc has been shown to suppress the output of prolactin from dispersed pituitary cells in vitro at physiologic concentrations. Clinical states associated with a tendency to zinc deficiency are also associated with a tendency to hyperprolactinemia. These observations are consistent with the hypothesis that prolactin regulates the uptake and distribution of zinc and that zinc suppresses prolactin in closure of a negative feedback regulatory loop.
M C Koppelman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  25     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-16     Completed Date:  1988-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Miriam Hospital, Providence, RI 02906.
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MeSH Terms
Hyperprolactinemia / physiopathology*
Pituitary Neoplasms / secretion
Prolactin / physiology*,  secretion
Zinc / deficiency,  metabolism*
Reg. No./Substance:
7440-66-6/Zinc; 9002-62-4/Prolactin

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