Document Detail


The potential role of homocysteine in percutaneous coronary interventions (PCI): review of current evidence and plausibility of action.
MedLine Citation:
PMID:  15704259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several millions of patients with coronary heart disease worldwide are treated by means ofpercutaneous interventions each year. Above all conventional balloon dilation and implantation of uncoated stents are, however, only of limited success as reflected by 6-month restenosis rates of 50% (balloon dilation) and 25-35% (bare-metal stent). It is therefore of utmost importance to identify high-risk groups and explore further secondary-prophylactic measures for the prevention of restenosis. A large body of evidence suggests that elevated homocysteine and/or folate and B-vitamin deficiencies are relevant risk factors for restenoses due to their proatherothrombotic potential. Hyperhomocysteinemia is an ideal target as this parameter can be lowered easily, safely and at a low cost by means of folate and B-vitamin supplementation. The results of published studies exploring a potential correlation between homocysteine levels and the risk of restenosis and those of interventional studies for the reduction of the risk of restenosis have not yet lead to consistent conclusions. However, a critical assessment can by no means exclude the plausibility of postinterventional lowering of homocysteine levels. This review aims at providing insight into the current evidence and biological plausibility of homocysteine-lowering therapy in regard to PCI-related vascular damage. Currently available clinical observational and interventional studies are reviewed in detail.
Authors:
O Stanger
Related Documents :
10894439 - Intravascular ultrasound predictors of major adverse cardiac events in patients with un...
8626949 - Mechanisms and immediate and long-term results of adjunct directional coronary atherect...
8037089 - Angiographic changes (dotter effect) produced by intravascular ultrasound imaging befor...
15390249 - Cutting balloon angioplasty vs. conventional balloon angioplasty in patients receiving ...
1414929 - Influence of vessel selection on the observed restenosis rate after endoluminal stentin...
15940049 - Anti-human leukocyte antigen antibodies are associated with restenosis after percutaneo...
16928169 - Use of the profunda femoris to facilitate closure of an antegrade puncture with the sta...
8284989 - Hormonal profile in mild heart failure.
3772419 - Cardiac metastases from soft-tissue sarcomas.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  50     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-10     Completed Date:  2005-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  France    
Other Details:
Languages:  eng     Pagination:  953-88     Citation Subset:  IM    
Affiliation:
Dept of Cardiac Surgery, Cardiovascular Research, St John's Hospital Salzburg, Private Medical University, Müllner Hauptstrasse 48, A-5020 Salzburg, Austria. o.stanger@salk.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angioplasty
Angioplasty, Transluminal, Percutaneous Coronary / methods
Animals
Clinical Trials as Topic
Coronary Angiography / methods*
Coronary Artery Disease / pathology
Coronary Restenosis / pathology*
Coronary Stenosis / pathology
Endothelium, Vascular / metabolism
Female
Homocysteine / blood,  metabolism,  physiology*
Homozygote
Humans
Hyperhomocysteinemia / metabolism
Male
Middle Aged
Models, Biological
Risk
Risk Factors
Vitamin B Complex / metabolism
Chemical
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of hyperhomocysteinemia in aortic disease.
Next Document:  Screening for proximal deep vein thrombosis after acute ischemic stroke: a prospective study using c...