Document Detail


The potential role of the detection of enterobacterial DNA in blood for the management of neonatal necrotizing enterocolitis.
MedLine Citation:
PMID:  22700552     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We present 3 cases of pre-term low-weight infants with suspected necrotizing enterocolitis (NEC) (1 eventually recognized as a connatal CMV infection), microbiologically monitored using a molecular assay detecting bacterial and fungal DNA in blood. The detection of DNA from enteric pathogens in blood was interpreted as a sign of ongoing perforation, and represented a useful complement in the management of the presented cases. Moreover, these cases suggest the opportunity of future larger studies to assess the possible role of a molecular approach in the close monitoring of infants with suspected NEC or with other conditions at-risk for intestinal perforation.
Authors:
Nicasio Mancini; Antonella Poloniato; Nadia Ghidoli; Silvia Carletti; Martina Fomasi; Graziano Barera; Rosanna Rovelli; Paola Cichero; Roberto Burioni; Massimo Clementi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  Journal of medical microbiology     Volume:  -     ISSN:  1473-5644     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Laboratorio di Microbiologia e Virologia, Univ. 'Vita-Salute' San Raffaele, Milano, Italia;
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