Document Detail


A potential role of the curry spice curcumin in Alzheimer's disease.
MedLine Citation:
PMID:  15974909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.
Authors:
John M Ringman; Sally A Frautschy; Gregory M Cole; Donna L Masterman; Jeffrey L Cummings
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current Alzheimer research     Volume:  2     ISSN:  1567-2050     ISO Abbreviation:  Curr Alzheimer Res     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2006-01-18     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  101208441     Medline TA:  Curr Alzheimer Res     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Affiliation:
University of California, Los Angeles, Department of Neurology, Alzheimer's Disease Research Center, Los Angeles, CA 90095, USA. jringman@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy*,  prevention & control
Animals
Clinical Trials, Phase II as Topic / methods
Curcuma*
Curcumin / chemistry,  isolation & purification,  therapeutic use*
Humans
Phytotherapy / methods
Spices
Grant Support
ID/Acronym/Agency:
AG 16570/AG/NIA NIH HHS; K08 AG022228-02/AG/NIA NIH HHS; K08 AG022228-03/AG/NIA NIH HHS; R01 AG013741-05/AG/NIA NIH HHS; R01 AG013741-06/AG/NIA NIH HHS; R01 NS043946-03/NS/NINDS NIH HHS; R01 NS043946-04/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
458-37-7/Curcumin
Comments/Corrections

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