| A potential role of the curry spice curcumin in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 15974909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology. |
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Authors:
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John M Ringman; Sally A Frautschy; Gregory M Cole; Donna L Masterman; Jeffrey L Cummings |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current Alzheimer research Volume: 2 ISSN: 1567-2050 ISO Abbreviation: Curr Alzheimer Res Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2006-01-18 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101208441 Medline TA: Curr Alzheimer Res Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Affiliation:
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University of California, Los Angeles, Department of Neurology, Alzheimer's Disease Research Center, Los Angeles, CA 90095, USA. jringman@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy*,
prevention & control Animals Clinical Trials, Phase II as Topic / methods Curcuma* Curcumin / chemistry, isolation & purification, therapeutic use* Humans Phytotherapy / methods Spices |
| Grant Support | |
ID/Acronym/Agency:
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AG 16570/AG/NIA NIH HHS; K08 AG022228-02/AG/NIA NIH HHS; K08 AG022228-03/AG/NIA NIH HHS; R01 AG013741-05/AG/NIA NIH HHS; R01 AG013741-06/AG/NIA NIH HHS; R01 NS043946-03/NS/NINDS NIH HHS; R01 NS043946-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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458-37-7/Curcumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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