Document Detail

A potential link between obesity and neural stem cell dysfunction.
MedLine Citation:
PMID:  23033050     Owner:  NLM     Status:  MEDLINE    
Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons--effects that are associated with activation of the IKKβ/NF-κB pathway--thereby exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity.
Frederick J Livesey
Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-01-11     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  987-9     Citation Subset:  IM    
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MeSH Terms
Diet, High-Fat
Feeding Behavior / physiology
Hypothalamus / physiopathology
I-kappa B Kinase / physiology
NF-kappa B / physiology
Neural Stem Cells / physiology*
Obesity / physiopathology*
Signal Transduction / physiology
Grant Support
079249//Wellcome Trust; 092096//Wellcome Trust; G0800784//Medical Research Council
Reg. No./Substance:
0/NF-kappa B; EC B Kinase

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