| A potential link between obesity and neural stem cell dysfunction. | |
| | |
MedLine Citation:
|
PMID: 23033050 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons - effects that are associated with activation of the IKKβ/NF-κB pathway - thereby exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity. |
| | |
Authors:
|
Frederick J Livesey |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nature cell biology Volume: 14 ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
|
Languages: eng Pagination: 987-9 Citation Subset: IM |
Affiliation:
|
Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Profilin phosphorylation as a VEGFR effector in angiogenesis.
Next Document: Assessment of quality of life with the multiple system atrophy health-related quality of life scale.