Document Detail

The potential of inorganic mass spectrometry in mineral and trace element nutrition research.
MedLine Citation:
PMID:  11496971     Owner:  NLM     Status:  MEDLINE    
Over the past two decades, new applications of inorganic mass spectrometry have been made possible by the use of stable isotopes as tracers in studies of mineral and trace element metabolism in man. Stable isotope techniques and radioisotope methods are the only reliable tools available for determination of the absorption, retention, or utilization of a nutrient by the human body. Recent developments in inorganic mass spectrometry might open new perspectives as progress in this field of research depends mainly on improving existing stable isotope techniques and on developing novel concepts. By improving precision in isotope analysis, isotope doses in experiments on man can be reduced to physiologically more meaningful levels. This will also enable reduction of the (often substantial) costs of isotopically labeling a nutrient in a test meal. Improvements in the mass spectrometric sensitivity will enable the development of new tracer techniques that have the potential to provide the information required by: 1. governmental institutions for designing food fortification programs; 2. the food industry for developing nutrient-fortified food products; and 3. public health authorities for establishing reliable dietary recommendations for intake of inorganic nutrients. In this context the current scope and limitations of thermal ionization mass spectrometry, inductively coupled mass spectrometry, accelerator mass spectrometry, and resonance ionization mass spectrometry are evaluated. Iron isotopic variations in the human body are discussed as a possible source of bias that might be a future biological limit to stable isotope-dose reduction in experiments on iron metabolism in man.
T Walczyk
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Fresenius' journal of analytical chemistry     Volume:  370     ISSN:  0937-0633     ISO Abbreviation:  Fresenius J Anal Chem     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-10     Completed Date:  2001-10-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9114077     Medline TA:  Fresenius J Anal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  444-53     Citation Subset:  IM    
Eidgenössische Technische Hochschule Zürich, Institut für Lebensmittelwissenschaften, Rüschlikon, Switzerland.
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MeSH Terms
Biological Availability
Iron Isotopes / analysis*
Isotopes / analysis
Mass Spectrometry
Minerals / analysis*
Nutritional Physiological Phenomena / physiology
Trace Elements / analysis*
Reg. No./Substance:
0/Iron Isotopes; 0/Isotopes; 0/Minerals; 0/Trace Elements

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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