Document Detail


The potential influence of gastric acid secretion during fasting on digestion time in leopard sharks (Triakis semifasciata).
MedLine Citation:
PMID:  17280858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vertebrates are known to differ in their response of gastric acid secretion during periods of fasting, yet the reasons for these differences remain unclear. Previously, continuous measurements of gastric pH in leopard sharks (Triakis semifasciata) had determined that acid secretion in this species is continuous. In order to determine if maintaining an empty acidic stomach may reduce digestion time of a subsequent meal, a simple descriptive model based on acid secretion rates was developed. In vivo gastric acid secretion rates were measured using an auto-titration technique. Acid secretion rates were pH dependent, with rates of 6.1+/-3.0 (+/-1 SD) mmol/h when gastric pH was >2.5, and 1.7+/-0.8 mmol/h when pH was 2.0-2.5. Analysis by Western blots suggests that pepsin secretion occurs within 1 h of feeding, and that there is a de-coupling of acid and pepsin secretion. The model estimates that digestion time can be reduced by 5.7+/-1.3 h and pepsin activity increased by 10-100% during that time if the stomach is acidic before feeding. Gastric acid secretion during fasting is hypothesized to reduce digestion time of a subsequent meal in frequently feeding sharks, which may be advantageous for exploiting resources that are spatially and temporally unpredictable.
Authors:
Yannis P Papastamatiou
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Publication Detail:
Type:  Journal Article     Date:  2006-11-28
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  147     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Affiliation:
Department of Zoology, Hawaii Institute of Marine Biology, University of Hawaii at Manoa, 46-007 Lilipuna Rd, Kaneohe, HI 96744, USA. yannis@hawaii.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Digestion / physiology*
Fasting / physiology*
Female
Gastric Acid / secretion*
Gastric Acidity Determination
Hydrogen-Ion Concentration
Models, Biological
Pepsin A / metabolism
Postprandial Period
Sharks / physiology*
Temperature
Chemical
Reg. No./Substance:
EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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