Document Detail


The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: a pilot study.
MedLine Citation:
PMID:  17415196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Ferumoxytol, an iron oxide nanoparticle that targets phagocytic cells, can be used in magnetic resonance imaging of malignant brain tumors and can be administered as a bolus, allowing dynamic imaging. Our objectives were to determine the optimum time of delayed contrast enhancement of ferumoxytol, and to compare ferumoxytol and gadolinium contrast agents for magnetic resonance angiography and perfusion. METHODS: Twelve patients with malignant brain tumors underwent serial magnetic resonance imaging multiple times up to 72 hours after ferumoxytol injection at both 1.5 and 3-T. The enhancement time course was determined for ferumoxytol and compared with a baseline gadolinium scan. Perfusion, time-of-flight and dynamic magnetic resonance angiography and T1-weighted scans were compared for the two agents. RESULTS: The lesions were detectable at all field strengths, even with an intraoperative 0.15-T magnet. Maximal ferumoxytol enhancement intensity was at 24 to 28 hours after administration, and the enhancing volume subsequently expanded with time into a non-gadolinium-enhancing, high T2-weighted signal region of tumor-infiltrated brain. Dynamic studies were assessed with both agents, indicating early vascular leak with gadolinium but not with ferumoxytol. CONCLUSION: Our most important finding was that gadolinium leaks out of blood vessels early after injection, whereas ferumoxytol stays intravascular in the "early" phase, thereby increasing the accuracy of tumor perfusion assessment. As a magnetic resonance imaging contrast agent, ferumoxytol visualizes brain tumors at all field strengths evaluated, with delayed enhancement peaking at 24 to 28 hours after administration.
Authors:
Edward A Neuwelt; Csanád G Várallyay; Sándor Manninger; Diána Solymosi; Marianne Haluska; Matthew A Hunt; Gary Nesbit; Alexander Stevens; Michael Jerosch-Herold; Paula M Jacobs; John M Hoffman
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neurosurgery     Volume:  60     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-11; discussion 611-2     Citation Subset:  IM    
Affiliation:
Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. neuwelte@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Neoplasms / diagnosis*
Contrast Media / administration & dosage
Feasibility Studies
Female
Ferrosoferric Oxide / administration & dosage*,  diagnostic use*
Gadolinium DTPA / administration & dosage*,  diagnostic use*
Humans
Image Enhancement / methods*
Magnetic Resonance Angiography / methods*
Male
Middle Aged
Nanoparticles / diagnostic use
Perfusion / methods
Pilot Projects
Grant Support
ID/Acronym/Agency:
N01-CO-12400/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 122795-43-1/gadodiamide; 1317-61-9/Ferrosoferric Oxide; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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