Document Detail

A potential explanation of some established major risk factors for autism.
MedLine Citation:
PMID:  22369368     Owner:  NLM     Status:  MEDLINE    
Baron-Cohen hypothesized that a cause of autism in infants is exposure to high concentrations of intrauterine testosterone concentrations. Some of the subsequent research on this hypothesis has focused on the possibility that the source of this testosterone is the fetus; however, this review shows that if the source is taken to be the mother, then many of the established risk factors for autism could be explained. If that were correct, it would follow that high maternally derived intrauterine androgen concentrations may be a major environmental cause of autism.
William H James
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-02-28
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  54     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-04-27     Revised Date:  2012-12-03    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Copyright Information:
© The Author. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
Department of Genetics, Evolution and Environment, University College, London, UK.
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MeSH Terms
Autistic Disorder / etiology*
Birth Order
Birth Weight
Continental Population Groups
Disease Susceptibility*
Emigration and Immigration
Models, Biological
Parent-Child Relations*
Pregnancy Complications
Prenatal Exposure Delayed Effects / physiopathology*
Risk Factors
Testosterone / adverse effects
Reg. No./Substance:
Comment In:
Dev Med Child Neurol. 2012 Nov;54(11):1068   [PMID:  22788982 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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