Document Detail

The potential for delivery of particulate matter through positive airway pressure devices (CPAP/BPAP).
MedLine Citation:
PMID:  21240657     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Airborne particulate matter may induce health risk with inhalation. Special concerns exist for deployed military personnel with inhaled particulate matter in desert environments. Continuous positive airway pressure (CPAP) used in obstructive sleep apnea may facilitate inhalation of particulate matter. We evaluated the ability of commercial CPAP filter systems to eliminate inhalation of particulate matter.
METHODS: An ultrasonic medical nebulizer (DeVilbliss Ultraneb, DeVilbliss, Somerset, PA) atomized liquid producing "respirable" aerosol. Technetium-99m diethylene triamine pentaacetic acid dissolved in water was also aerosolized to quantify aerosol inhalation. A high efficiency particulate air (HEPA) filter placed at the patient-hose connection port in the bilevel positive airway pressure (BPAP) device captured the aerosol inbound to the patient. The HEPA filter provided a means to quantify aerosol dose delivered to a simulated patient. Commercial foam and ultrafine filters were assessed with aerosol to determine the simulated patient exposure.
RESULTS: Foam and ultrafine filters used together allowed 1.5% or less of aerosol volume to pass through the BPAP system. Foam filters alone allowed an average of 18.9% of aerosol delivered to pass through the BPAP system.
CONCLUSIONS: Foam and ultrafine filters used together in BPAP systems provide excellent aerosol filtration in this laboratory simulation of BPAP use.
David Kristo; Timothy Corcoran; Nina O'Connell; Kristina Thomas; Patrick Strollo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-01-16
Journal Detail:
Title:  Sleep & breathing = Schlaf & Atmung     Volume:  16     ISSN:  1522-1709     ISO Abbreviation:  Sleep Breath     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-07-24     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  9804161     Medline TA:  Sleep Breath     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
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MeSH Terms
Continuous Positive Airway Pressure / instrumentation*
Equipment Design
Filtration / instrumentation*
Nebulizers and Vaporizers
Particle Size
Particulate Matter*
Sleep Apnea, Obstructive / therapy*
Technetium Tc 99m Pentetate / diagnostic use
Grant Support
Reg. No./Substance:
0/Dust; 0/Particulate Matter; VW78417PU1/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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