| The potential of azole antifungals against latent/persistent tuberculosis. | |
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MedLine Citation:
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PMID: 16640573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate the chemotherapeutic potential of econazole against latent tuberculosis. The activity of econazole and clotrimazole was tested against the latent bacilli (Mycobacterium tuberculosis H(37)Rv) developed by nutrient starvation under in vitro conditions and by drugs under in vivo conditions. The latent bacteria developed under in vitro latent conditions were acid-fast negative, nonreplicating, resistant to conventional antitubercular drugs and showed low respiration rates. Econazole as well as clotrimazole were found to have strong antimycobacterial potential against latent Mycobacterium tuberculosis under in vitro conditions as seen by reductions in colony-forming units. Further, econazole prevented the formation of drug-induced latency and significantly reduced bacterial burden from lungs and spleens of latent tuberculosis-infected mice. We conclude that azole drugs bear significant therapeutic potential against latent tuberculosis. |
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Authors:
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Zahoor Ahmad; Sadhna Sharma; Gopal K Khuller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS microbiology letters Volume: 258 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-27 Completed Date: 2006-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 200-3 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antitubercular Agents / pharmacology, therapeutic use* Clotrimazole / pharmacology, therapeutic use* Colony Count, Microbial Econazole / pharmacology, therapeutic use* Lung / microbiology Mice Mycobacterium tuberculosis / drug effects Spleen / microbiology Tuberculosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents; 23593-75-1/Clotrimazole; 27220-47-9/Econazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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