Document Detail


The potential of D-dimer levels as a useful clinical marker of clotting state after the return of sinus rhythm.
MedLine Citation:
PMID:  19804132     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fibrin D-dimers levels have been advocated as a useful clinical marker of thrombogenesis. It is accepted that patients with atrial fibrillation (AF) are characterized by increased levels of plasmatic d-dimers. AF is a high risk factor for hypercoagulability, with a substantial risk of thromboembolism. The most effective way of minimizing the increased thromboembolic risk and treating patients' symptoms is to return the heart rhythm to sinus rhythm by electrical or chemical cardioversion. However, cardioversion of AF itself leads to a further increased risk of thromboembolism. A marker of coagulation activation would be useful to identify patients at the highest thromboembolic risk after cardioversion in AF patients. Indicators of hypercoagulability, such as d-dimers, appear to be a useful parameter for assessing the degree of hypercoagulability of AF patients after cardioversion. Mean changes in plasma d-dimers levels could be used as a useful clinical marker of the clotting state after the return of atrial systole.
Authors:
Eleni Hatzinikolaou-Kotsakou; Dimitrios I Hatseras
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future cardiology     Volume:  2     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2009-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  -    
Affiliation:
Academic General Hospital, Alexandroupolis, Demokritus University of Thrace-Greece, Dragana 68100Alexandroupolis, Greece. kokoy@otenet.gr
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