Document Detail


The potent synergistic effects of the combination of liraglutide and canagliflozin on glycemic control and weight loss.
MedLine Citation:
PMID:  24753783     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PATIENT: Male, 57 FINAL DIAGNOSIS: Diabetes mellitus type 2 SYMPTOMS: Weight loss Medication: - Clinical Procedure: - Specialty: Endocrinology and Metabolic.
OBJECTIVE: Unusual or unexpected effect of treatment.
BACKGROUND: Studies of the efficacy of the combination of the incretin mimetic liraglutide and the SGLT2 inhibitor canagliflozin or indeed studies of the combination of any incretin mimetic with an SGLT2 inhibitor have neither been performed nor published. Pharmacologically, the combination of an incretin-mimetic and an SGLT2-receptor blocker should result in a more significant weight loss and a greater reduction in postprandial glucose and HbA1c.
CASE REPORT: An insulin-dependent type 2 diabetic patient with multiple diabetic complications was placed on the combination of liraglutide and canagliflozin and 4 weeks later was able to discontinue insulin. In addition, in spite of discontinuing insulin, his HbA1c dropped from 7.0% to 6.8%, and he had reductions in body (weight from 247 to 218 lbs), BMI (from 34 to 29.5 Kg/m(2)), waist circumference (from 47 to 44 ½ inches), and neck circumference (from 19 ½ to 18 ¼ inches).
CONCLUSIONS: The combination of an SGLT2 inhibitor and an incretin mimetic/analog results in improved glycemic control accompanied by significant weight loss. This combination needs to be studied in a prospective randomized trial because the effect of each of the components of this combination is synergistically magnified by the addition of the partner drug.
Authors:
David S H Bell
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Publication Detail:
Type:  Journal Article     Date:  2014-04-14
Journal Detail:
Title:  The American journal of case reports     Volume:  15     ISSN:  1941-5923     ISO Abbreviation:  Am J Case Rep     Publication Date:  2014  
Date Detail:
Created Date:  2014-04-22     Completed Date:  2014-04-22     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  101489566     Medline TA:  Am J Case Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-4     Citation Subset:  -    
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