| The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 12691930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity. STUDY DESIGN: Our aim was to determine if vapreotide, a potent long-acting somatostatin analogue, would decrease pancreas-related complications. This prospective, multicenter, randomized, double-blind, placebo-controlled trial involved 275 patients without preexisting chronic pancreatitis undergoing elective proximal, central, or distal pancreatectomy. Complications were defined by objective criteria before beginning the study. RESULTS: One hundred thirty-five patients received vapreotide; 140 patients received placebo. There were no statistically significant differences between vapreotide- and placebo-treated patients in either pancreas-related complications (30.4% versus 26.4%, respectively) or in other complications not directly related to the pancreas (40% versus 42%, respectively). CONCLUSIONS: The potent somatostatin analogue vapreotide does not appear to decrease postoperative complications after major pancreatectomy in patients without chronic pancreatitis. |
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Authors:
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Micheal G Sarr; |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Surgeons Volume: 196 ISSN: 1072-7515 ISO Abbreviation: J. Am. Coll. Surg. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-14 Completed Date: 2003-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431305 Medline TA: J Am Coll Surg Country: United States |
Other Details:
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Languages: eng Pagination: 556-64; discussion 564-5; author reply 565 Citation Subset: AIM; IM |
Affiliation:
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Gastroenterology Research Unit (AL 2-436), Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Female Humans Logistic Models Male Middle Aged Pancreatectomy* Postoperative Complications / epidemiology, prevention & control* Prospective Studies Risk Factors Somatostatin / analogs & derivatives*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/vapreotide; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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