Document Detail


The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food.
MedLine Citation:
PMID:  22205211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The selective serotonin reuptake inhibitor fluvoxamine reduces responding for ethanol at lower doses than responding for food when each is available in separate components or separate groups of rats. However, when both are available concurrently and deliveries earned per session are equal, this apparent selectivity inverts and food-maintained behavior is more sensitive than ethanol-maintained behavior to rate-decreasing effects of fluvoxamine. Here, we investigated further the impact that concurrent access to both food and ethanol has on the potency of fluvoxamine. Fluvoxamine (5.6-17.8 mg/kg) potency was assessed under conditions in which food and ethanol were available concurrently and response rates were equal [average variable intervals (VIs) 405 and 14 s for food and ethanol, respectively], as well as when density of food delivery was increased (average VI 60 s for food and VI 14 s for ethanol). The potency of fluvoxamine was also determined when only ethanol was available (food extinction and average VI 14 s for ethanol) and under multiple VIs (VI 30 s for food and ethanol) wherein either food or ethanol was the only programmed reinforcement available during each component. Fluvoxamine was less potent at decreasing ethanol self-administration when food was available concurrently {ED50 [95% confidence limit (CL): 8.2 (6.5-10.3) and 10.7 (7.9-14.4)]} versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.
Authors:
Brett C Ginsburg; Jonathan W Pinkston; Richard J Lamb
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  23     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-07-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-42     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, San Antonio 78229, USA. ginsburg@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / drug effects*
Dose-Response Relationship, Drug
Ethanol / administration & dosage,  antagonists & inhibitors*,  pharmacology
Extinction, Psychological / drug effects
Fluvoxamine / pharmacology*
Food*
Male
Rats
Rats, Inbred Lew
Reinforcement (Psychology)*
Reinforcement Schedule
Self Administration
Serotonin Uptake Inhibitors / pharmacology*
Grant Support
ID/Acronym/Agency:
AA012337/AA/NIAAA NIH HHS; AA015993/AA/NIAAA NIH HHS; R01 AA012337-05/AA/NIAAA NIH HHS; R03 AA015993/AA/NIAAA NIH HHS; R03 AA015993-01A2/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine; 64-17-5/Ethanol
Comments/Corrections

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