Document Detail

The postradiation effect of noradrenaline, serotonin and dopamine on the activity of the Na-K pump in rat brain slices
MedLine Citation:
PMID:  8392736     Owner:  NLM     Status:  MEDLINE    
Whole-body X irradiation with doses of 0.155 and 0.310 C/kg was shown to modify in different ways the activating effects of noradrenaline and serotonin, as well as a biphase effect of dopamine (5.10(-8)--1.5.10(-3) M) on Na,K-pump of neuronal membranes. The resulting effect was a function of a combination of radiation doses and neurotransmitter concentrations and thus showed different modes of interaction between neurotransmitter and ion-transport systems of brain cells in radiation sickness. The authors discuss possible molecular mechanisms of radiation modification of the functional interaction between the neurotransmitter and the active ion-transport systems in nerve cells.
A I Dvoretskiĭ; I A Kulikova
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Radiobiologiia     Volume:  33     ISSN:  0033-8192     ISO Abbreviation:  Radiobiologiia     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-08-17     Completed Date:  1993-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401251     Medline TA:  Radiobiologiia     Country:  RUSSIA    
Other Details:
Languages:  rus     Pagination:  402-7     Citation Subset:  IM    
Vernacular Title:
Postradiatsionnyĭ éffekt noradrenalina, serotonina i dofamina na aktivnost' Na,K-nasosa srezov mozga krys.
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MeSH Terms
Biological Transport, Active / drug effects,  radiation effects
Brain / drug effects*,  metabolism,  radiation effects*
Dopamine / pharmacology*
Dose-Response Relationship, Radiation
Neurons / drug effects,  metabolism,  radiation effects
Norepinephrine / pharmacology*
Potassium / metabolism,  radiation effects
Rats, Wistar
Serotonin / pharmacology*
Sodium-Potassium-Exchanging ATPase / drug effects*,  radiation effects*
Time Factors
Whole-Body Irradiation
Reg. No./Substance:
50-67-9/Serotonin; 51-41-2/Norepinephrine; 7440-09-7/Potassium; EC ATPase

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