| Is postoperative cognitive dysfunction a risk factor for dementia? A cohort follow-up study. | |
| | |
MedLine Citation:
|
PMID: 23274780 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: /st>Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients after major surgery. An association between POCD and the development of dementia has been suspected. In this study, we assessed if POCD was a risk factor for the occurrence of dementia. METHODS: /st>Danish patients enrolled between November 1994 and October 2000 in the two International Studies of Postoperative Cognitive Dysfunction (ISPOCD 1 and 2) were followed until July 1, 2011. Cognitive performance was assessed at three time points: before operation, at 1 week, and 3 months after surgery, using a neuropsychological test battery. The time of (first) occurrence of dementia after surgery was assessed using the National Patient Register and the Psychiatric Central Research Register. Recorded dementia diagnoses (ICD-8 and ICD-10) were: Alzheimer's disease, vascular dementia, frontotemporal dementia, or dementia without specification. The risk of dementia according to POCD was assessed in the Cox regression models. RESULTS: /st>A total of 686 patients with a median age of 67 [inter-quartile range (IQR) 61-74] yr were followed for a median of 11.1 (IQR 5.2-12.6) yr. Only 32 patients developed dementia during follow-up. The hazard ratio (95% CI) for any dementia diagnoses in patients with POCD at 1 week (n=118) and POCD at 3 months (n=57) after surgery compared with those without POCD was 1.16 (0.48-2.78), P=0.74, and 1.50 (0.51-4.44); P=0.47, respectively. CONCLUSIONS: /st>POCD was not significantly associated with registered dementia over a median follow-up of 11 yr. |
| | |
Authors:
|
J Steinmetz; V Siersma; L V Kessing; L S Rasmussen; |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-28 |
Journal Detail:
|
Title: British journal of anaesthesia Volume: - ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Anaesthesia, Center of Head and Orthopaedics, HOC 4231 and. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical assessment of a CMC/PEO gel to inhibit postoperative epidural adhesion formation after lumb...
Next Document: Predictive factors of symptomatic cerebral hyperperfusion after superficial temporal artery-middle c...