Document Detail

Is postconditioning effective in prevention against long-lasting myocardial ischemia in the rabbit?
MedLine Citation:
PMID:  19093726     Owner:  NLM     Status:  In-Process    
The goal of the study was to determine whether postconditioning protects against different ischemia durations in the rabbit. Rabbits were assigned to a 20-, 25-, 45- or 60-min coronary occlusion followed by 24-h of reperfusion. Rabbits received no further intervention (control) or were postconditioned with four cycles of 30-s occlusion and 30-s reperfusion after myocardial infarction. Plasma levels of troponin I were quantified throughout reperfusion. In control conditions, infarct sizes (% area at risk using triphenyltetrazolium chloride) after 20, 25, 45 and 60 min of coronary occlusions were 23+/-3, 51+/-4, 70+/-3 and 81+/-3 %, respectively. With 20 and 25 min occlusion, postconditioning reduced infarct size by 43+/-10 and 73+/-21 %, respectively. On the other hand, with 45 or 60 min occlusion, postconditioning had no significant effects on infarct size (61+/-3 and 80+/-2 % of area at risk). Preconditioning protocol was performed with 25- and 60-min coronary occlusion. As expected, preconditioning significantly reduced infarct size. In conclusion, in the rabbit, the cardioprotection afforded by postconditioning is limited to less than 45 min coronary occlusion.
R L??tienne; Y Calmettes; B Le Grand
Related Documents :
8498546 - Adenosine a1 receptors, katp channels, and ischemic preconditioning in dogs.
12684266 - Oral nicorandil recaptures the waned protection from preconditioning in vivo.
10391276 - Ischemic preconditioning reduces neutrophil accumulation and myocardial apoptosis.
20230376 - Cardioprotection by regular ethanol consumption: potential mechanisms and clinical appl...
23097076 - High signal intensity on t2-weighted cardiac magnetic resonance imaging correlates with...
904036 - Therapeutic renal infarction.
Publication Detail:
Type:  Journal Article     Date:  2008-11-04
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  58     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  635-43     Citation Subset:  IM    
Centre de Recherche Pierre Fabre, 17 Av. Jean Moulin, 81106 Castres, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peroxidative damage of mitochondrial respiration is substrate-dependent.
Next Document:  GnRH-I and GnRH-II-induced calcium signaling and hormone secretion in neonatal rat gonadotrophs.