Document Detail


Is postconditioning effective in prevention against long-lasting myocardial ischemia in the rabbit?
MedLine Citation:
PMID:  19093726     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The goal of the study was to determine whether postconditioning protects against different ischemia durations in the rabbit. Rabbits were assigned to a 20-, 25-, 45- or 60-min coronary occlusion followed by 24-h of reperfusion. Rabbits received no further intervention (control) or were postconditioned with four cycles of 30-s occlusion and 30-s reperfusion after myocardial infarction. Plasma levels of troponin I were quantified throughout reperfusion. In control conditions, infarct sizes (% area at risk using triphenyltetrazolium chloride) after 20, 25, 45 and 60 min of coronary occlusions were 23+/-3, 51+/-4, 70+/-3 and 81+/-3 %, respectively. With 20 and 25 min occlusion, postconditioning reduced infarct size by 43+/-10 and 73+/-21 %, respectively. On the other hand, with 45 or 60 min occlusion, postconditioning had no significant effects on infarct size (61+/-3 and 80+/-2 % of area at risk). Preconditioning protocol was performed with 25- and 60-min coronary occlusion. As expected, preconditioning significantly reduced infarct size. In conclusion, in the rabbit, the cardioprotection afforded by postconditioning is limited to less than 45 min coronary occlusion.
Authors:
R L??tienne; Y Calmettes; B Le Grand
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Publication Detail:
Type:  Journal Article     Date:  2008-11-04
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  58     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  635-43     Citation Subset:  IM    
Affiliation:
Centre de Recherche Pierre Fabre, 17 Av. Jean Moulin, 81106 Castres, France. robert.letienne@pierre-fabre.com
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