Document Detail


The postantibiotic effect of fusidic acid against gram-positive bacteria.
MedLine Citation:
PMID:  9338499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in-vitro postantibiotic effect (PAE) of fusidic acid was tested for six strains of Staphylococcus aureus and four strains of Streptococcus pyogenes. The maximum PAE that could be achieved was more than 3 h, but at concentrations of antibiotic attainable in humans, the PAE was less than 2 h. Additional experiments were performed in albumin, to examine the effect of the strong protein binding of fusidic acid on the MIC and PAE. MICs were increased, but at the same multiple of the MIC, PAEs were similar to those performed in Mueller-Hinton broth.
Authors:
W J Munckhof; J D Turnidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  40     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-30     Completed Date:  1998-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Infectious Diseases, Monash Medical Centre, Melbourne, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Fusidic Acid / pharmacology*
Microbial Sensitivity Tests / methods
Staphylococcus aureus / drug effects*
Streptococcus pyogenes / drug effects*
Chemical
Reg. No./Substance:
6990-06-3/Fusidic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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