Document Detail

The post-thrombotic syndrome - a condition to prevent.
MedLine Citation:
PMID:  18627714     Owner:  NLM     Status:  MEDLINE    
The incidence of the post-thrombotic syndrome (PTS) is increasing along with the incidence of deep vein thrombosis (DVT). The overall frequency of PTS ranges from 20 percent to 50 percent of DVT patients; severe PTS, which includes leg ulcers, occurs in a quarter of cases. Because of its severity and chronicity, PTS is associated with great morbidity and cost. Its diagnosis is primarily based on the presence of typical symptoms and signs, but objective evidence of venous valvular reflux can help to confirm the diagnosis. Because therapeutic options for PTS are extremely limited and results are often disappointing, prevention, recognition of clinical signs or complications, and early treatment remain the keys to reducing its morbidity. The prevention of DVT recurrence by anticoagulation and use of graduated compression stockings is likely to reduce the risk of PTS. There is no proven role for thrombolysis in preventing PTS.
Delphine Pirard; Bernard Bellens; Pierre Vereecken
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-15
Journal Detail:
Title:  Dermatology online journal     Volume:  14     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13     Citation Subset:  IM    
Department of Dermatology, Erasme hospital, Université Libre de Bruxelles Brussels, Belgium.
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MeSH Terms
Anticoagulants / therapeutic use
Erysipelas / etiology,  pathology
Leg Dermatoses / etiology,  pathology
Lymphangiosarcoma / etiology
Lymphedema / etiology,  pathology
Postthrombotic Syndrome* / diagnosis,  etiology,  prevention & control
Skin / pathology*
Skin Care
Skin Neoplasms / etiology
Stockings, Compression
Venous Thrombosis / complications*,  therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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