Document Detail

The post-operative analgesic effects of epidurally administered morphine and transdermal fentanyl patch after ovariohysterectomy in dogs.
MedLine Citation:
PMID:  21040380     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To investigate the analgesic and side effects of epidural morphine or a fentanyl patch after ovariohysterectomy in dogs.
STUDY DESIGN: Prospective, randomized clinical study.
ANIMALS: Twenty female mongrel dogs undergoing ovariohysterectomy.
METHODS: The dogs were allocated to one of two groups: epidural morphine or transdermal fentanyl patch. Anaesthesia was induced with propofol and maintained with isoflurane. Morphine (0.1 mg kg(-1)) was administered epidurally in the epidural morphine group and a transdermal fentanyl patch was applied 24 hours before the operation in the fentanyl patch group. The heart rate, respiratory rate, body temperature, plasma cortisol concentration, and sedation and analgesia scores were recorded during the 24 hour post-operative period. Adverse effects such as vomiting, anorexia, skin reactions, urinary retention, and time to start licking the surgical site were also recorded. p<0.05 was considered significant. Statistical analyses utilized anova for repeated measures, Friedman tests, Mann-Whitney U-tests and independent sample t-tests as relevant.
RESULTS: Pain scores were lower in the epidural group than in the fentanyl group at all post-operative times. The dogs in the epidural morphine group were calm and relaxed, whereas discomfort and vocalization were recorded in the fentanyl patch group. The sedation scores were higher in the fentanyl patch group throughout the 12 hour period. Salivation and anorexia lasted longer in the fentanyl patch group than in the epidural morphine group. Plasma cortisol concentrations were high in the early post-operative period in both groups. The fentanyl patch group had higher cortisol concentrations than the epidural morphine group. Slight erythema was recorded in two dogs when the patches were removed.
CONCLUSION AND CLINICAL RELEVANCE: Epidurally administered morphine provided better analgesia and caused fewer adverse effects than the fentanyl patch after ovariohysterectomy in dogs.
Zeynep Pekcan; Bahattin Koc
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  37     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-65     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Veterinary Anaesthesia and Analgesia © 2010 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.
Department of Surgery, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey.
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