| The possible study of HuaXi-1 solution for all intra-abdominal organ preservation: a study in rats. | |
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MedLine Citation:
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PMID: 16980049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: University of Wisconsin (UW) solution continues to be the most commonly used solution for intra-abdominal organs. However, it is expensive. Therefore, we have formulated HuaXi-1 (HX-1) solution. The aim of this research was to assess the effect of HX-1 solution compared to UW, Collins 2, and hypertonic citrate solutions on intra-abdominal organs. METHODS: The effects of HX-1 solution for all intra-abdominal organ preservation were studied in a noncirculated, isolated, perfused rat liver model, in rat pancreas isografts in diabetic rats, and in a kidney autotransplant model. The effects were investigated by measuring hepatic tissue water content, sinusoidal lining cell mortality, Krebs-Henseleits perfusate, aspartate aminotransferase, the number of livers secreting bile during isolated perfusion, blood glucose, glucose tolerance tests, serum insulin of the rat pancreas-transplant recipients, the maximum serum creatinine levels, kidney graft survival rates, and observing the morphological changes in liver, pancreas, and kidneys. RESULTS: HX-1 solution preserved rat liver well for 24 hours as effectively as UW, rat pancreas as well for 48 hours, and dog kidney as well for 72 hours. CONCLUSION: The experimental findings indicated that HX-1 solution was effective to preserve all intra-abdominal organs; it may simplify cold storage of organs for transplantation. |
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Authors:
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B Peng; R Zhang; X Wang; W Sheng; H Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2226-30 Citation Subset: IM |
Affiliation:
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Department of Surgery, West China Hospital, West China Medical School, SiChuan University, Guoxuexiang 37, Chengdu 610041, P.R. China. Pengbing84@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Adenosine Allopurinol Animals Blood Glucose / metabolism Diabetes Mellitus, Experimental / surgery Drugs, Chinese Herbal / pharmacology* Glutathione Graft Survival / drug effects, physiology Insulin Liver Transplantation / physiology* Models, Animal Organ Preservation Solutions Pancreas Transplantation / physiology* Raffinose Rats |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Drugs, Chinese Herbal; 0/Organ Preservation Solutions; 0/University of Wisconsin-lactobionate solution; 11061-68-0/Insulin; 315-30-0/Allopurinol; 512-69-6/Raffinose; 58-61-7/Adenosine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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