Document Detail

The possible significance of cytomegaloviral parotitis in infant and early childhood deaths.
MedLine Citation:
PMID:  9431318     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether cytomegaloviral (CMV) parotitis reflects a disseminated disease that increases vulnerability to unexpected death. DESIGN: Necropsy-based cross-sectional study comparing incidences of brain stem microglial nodules and visceral lymphocytic infiltrates in patients with and without CMV parotitis. SUBJECTS: One hundred twelve infants and young children comprising a study group of 40 individuals with CMV parotitis (including 32 whose deaths remained unexplained) and two comparison groups comprising 40 explained and 32 unexplained deaths. MAIN OUTCOME MEASURES: Incidence and variation with age of brain stem microglial nodules and lymphocytic infiltrates in liver and kidneys. RESULTS: Brain stem microglial nodules and lymphocytic infiltrates in liver and kidneys are strongly associated with CMV parotitis; their incidence diminishes with increasing age. CONCLUSIONS: Disseminated disease frequently accompanies CMV parotitis in infants. The resolution of brain stem microglial nodules precedes that of parotitis. Active and previous brain stem involvement may increase vulnerability to unexpected death.
S Variend; D O'Neill; P Arnold
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  121     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-04     Completed Date:  1998-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1272-6     Citation Subset:  AIM; IM    
Department of Histopathology, Sheffield Children's Hospital, England.
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MeSH Terms
Aging / pathology
Brain Stem / pathology,  physiopathology
Child, Preschool
Cross-Sectional Studies
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / mortality*,  pathology*,  virology
Infant, Newborn
Kidney / pathology
Liver / pathology
Lymphocytes / pathology
Microglia / pathology
Parotid Gland / pathology,  virology
Parotitis / mortality*,  pathology*,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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