Document Detail

A possible role for prolactin in the control of human chorionic gonadotropin and estrogen secretion by the fetoplacental unit.
MedLine Citation:
PMID:  7352519     Owner:  NLM     Status:  MEDLINE    
The effects of prolactin (PRL) on fetoplacental function were studied by measuring the beta subunit of human chorionic gonadotropin (hCG-beta), estradiol (E2), progesterone (P), and PRL concentrations throughout seven pregnancies in a control group (N = 6 women) and in three pregnant women with prolactinomas, who were receiving bromocriptine. In one of the latter, estriol (E3) was also assayed. Long-term suppression of PRL was associated with augmentation of hCG-beta at the first-treimester peak and in late pregnancy. Concomitant augmentation of E3 (in late gestation) and possibly E2, but not P, levels was also observed. This effect on hCG appeared dependent on PRL rather than the dopaminergic effect of bromocriptine. Short-term drug induced alterations in PRL (over 3 hours) during early pregnancy did not result in significant changes in hCG-beta or steroid concentrations. In each control pregnancy, a significant negative correlation (p less than 0.05) was observed between hCG-beta and PRL, while a significant positive correlation between the latter and E2 concentrations in these women was also demonstrated. Apart from its effect on lactation, osmoregulation, and gonadal and adrenal function, a further role for PRL during reproduction appears to be in the control of hCG and estrogen secretion in the fetoplacental unit.
B Ho Yuen; W Cannon; J Lewis; L Sy; S Woolley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  136     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  286-91     Citation Subset:  AIM; IM    
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MeSH Terms
Anovulation / physiopathology
Bromocriptine / pharmacology
Chlorpromazine / pharmacology
Chorionic Gonadotropin / analysis,  secretion*
Estrogens / analysis,  secretion*
Fetus / metabolism
Infertility, Female / physiopathology
Pituitary Neoplasms / physiopathology
Placental Hormones / secretion*
Pregnancy Complications / physiopathology
Prolactin / physiology*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Estrogens; 0/Placental Hormones; 25614-03-3/Bromocriptine; 50-53-3/Chlorpromazine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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