| A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20651816 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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It is believed that amyloid-beta peptide (Abeta) plays a central role in the pathogenesis of Alzheimer's disease (AD). Thus, the process of amyloid precursor protein (APP) cleavage is a key event and has raised much attention in the field of AD research. It is proposed that APP, beta- and gamma-secretases are all located on the lipid raft, and the meeting of them is an indispensable step for Abeta generation. Endocytosis can lead to clustering of APP, beta- and gamma-secretases from separate smaller lipid rafts into a larger one. On the other hand, for myristoylated alanine-rich C kinase substrate (MARCKS), phosphorylation by protein kinase C (PKC) or interaction with Ca(2+) can lead to its release from membrane into cytoplasm. This process induces the release of actins and phosphatidylinositol 4, 5-bisphosphate (PIP2), which are important factors for endocytosis. Thus, the present review proposes that MARCKS may be implicated in Abeta generation, by modulating free PIP2 level and actin movement, causing endocytosis. |
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Authors:
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Rui Su; Zhen-Yun Han; Ji-Ping Fan; Yun-Ling Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience bulletin Volume: 26 ISSN: 1995-8218 ISO Abbreviation: Neurosci Bull Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256850 Medline TA: Neurosci Bull Country: China |
Other Details:
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Languages: eng Pagination: 338-44 Citation Subset: IM |
Affiliation:
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China Academy of Chinese Medical Sciences, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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