Document Detail

The possible role of myocardial biopsy in systemic sclerosis.
MedLine Citation:
PMID:  10888714     Owner:  NLM     Status:  MEDLINE    
The histopathological features of heart involvement in systemic sclerosis (SSc) are not widely known. In internal and transplantation medicine, myocardial biopsies are increasingly used to diagnose cardiomyopathies including myocarditis. In two SSc patients presenting with dyspnoea with no evidence of pulmonary involvement, the cause of the compromised heart function was sought by myocardial biopsy. Immunohistological analysis revealed an increased number of CD3+ + T cells indicating myocarditis in one, and increased amounts of fibroblasts in both SSc patients. The authors think that myocardial involvement in SSc should be differentially evaluated and they propose the use of myocardial biopsies as a tool to distinguish between inflammatory and fibrotic forms of heart involvement in SSc patients.
O Liangos; L Neure; U Kühl; M Pauschinger; J Sieper; A Distler; P L Schwimmbeck; J Braun
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  39     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  674-9     Citation Subset:  AIM; IM    
Department of Nephrology and Rheumatology, Freie Universität Berlin, Berlin, Germany.
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MeSH Terms
Antigens, CD3 / analysis
Fibrosis / etiology,  pathology
Middle Aged
Myocarditis / etiology,  pathology
Myocardium / metabolism,  pathology*
Scleroderma, Systemic / complications,  pathology*
T-Lymphocytes / pathology
Reg. No./Substance:
0/Antigens, CD3

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