Document Detail

A possible role for leukotrienes in the regulation of glomerular haemodynamics in the dog.
MedLine Citation:
PMID:  2845354     Owner:  NLM     Status:  MEDLINE    
In anaesthetized beagles, saralasin, phentolamine, 1-penicillamine-2-O-methyl-tyrosine-8-arginine-vasopressin and SCH 23390, a DA1 antagonist, were infused into the left renal artery (i.r.a.) and indomethacin and aprotinin intravenously (Group 1). In Groups 2 and 3, i.r.a. infusion of two chemically different putative leukotriene (LT) antagonists, FPL 55712 (100 micrograms/kg/min) and LY 171883 (500 micrograms/kg/min), respectively, was superimposed in the fourth period of experiments. In comparison to Group 1, there was an increase (40% in Group 2 and 33% in Group 3) in renal blood flow and a decrease in glomerular filtration rate (16% and 17%, respectively) and filtration fraction (36% and 41%, respectively). Similar changes were observed on the single nephron level. Directly measured glomerular capillary pressure decreased by 10% and 12%, respectively. A decrease in total arteriolar resistance by 34% and 25%, respectively, was caused by a comparatively higher decrease in efferent (44% and 34%, respectively) than afferent (26% and 15%, respectively) arteriolar resistance values. No change in the ultrafiltration coefficient, Kf, was detected. Providing FPL 55712 and LY 171883 are specific LT antagonists, these experiments suggest a possible constrictory role of LT (expressed more on the efferent than afferent arteriole) in anaesthetised mildly surgically stressed dogs.
J Heller; V Horácek; S Kamarádová
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  412     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
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MeSH Terms
Acetophenones / pharmacology
Chromones / pharmacology
Hemodynamics / drug effects*
Infusions, Intra-Arterial
Kidney Glomerulus / drug effects,  physiology*
Leukotriene E4
Nephrons / drug effects,  physiology
SRS-A / analogs & derivatives*,  antagonists & inhibitors,  physiology*
Tetrazoles / pharmacology
Reg. No./Substance:
0/Acetophenones; 0/Chromones; 0/SRS-A; 0/Tetrazoles; 40786-08-1/FPL 55712; 75715-89-8/Leukotriene E4; 88107-10-2/LY 171883

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