Document Detail

A possible role of immunoglobulin E in patients with hyperthyroid Graves' disease.
MedLine Citation:
PMID:  10523002     Owner:  NLM     Status:  MEDLINE    
To investigate the possible participation of immunoglobulin E (IgE) in the autoimmune process of Graves' disease, incidence of elevation of serum IgE level, TSH receptor antibody (TRAb), and thyroid status were studied in 66 patients with hyperthyroid Graves' disease, 54 patients with Hashimoto's thyroiditis, 19 patients with bronchial asthma, and 15 patients with pollen allergy. In hyperthyroid Graves' patients, elevation of serum IgE levels (> or = 170 U/mL) was found in 19 of 66 patients (29%), 11 of whom had hereditary and/or allergic conditions. Elevations of serum IgE levels were found in 63% of patients with bronchial asthma and in 40% of patients with pollen allergy. Mean values of serum IgE were the same in patients with hyperthyroid Graves' disease and with bronchial asthma. During methimazole treatment TRAb decreased without fluctuation of IgE levels in both groups. The decrease in TRAb was significantly greater in patients with normal IgE than in patients with IgE elevation. After prednisone administration, reduction in TRAb was greater in patients with normal IgE than that in patients with IgE elevation. High incidence of IgE elevation in hyperthyroid Graves' disease and slower reduction in TRAb in association with IgE elevation suggest a difference in the autoimmune processes in Graves' disease with and without elevation of IgE.
A Sato; Y Takemura; T Yamada; H Ohtsuka; H Sakai; Y Miyahara; T Aizawa; A Terao; S Onuma; K Junen; A Kanamori; Y Nakamura; E Tejima; Y Ito; K Kamijo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  84     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3602-5     Citation Subset:  AIM; IM    
Department of Medicine, Dokkyo Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
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MeSH Terms
Antithyroid Agents / therapeutic use
Asthma / blood,  drug therapy
Glucocorticoids / therapeutic use
Graves Disease / blood,  drug therapy,  physiopathology*
Hypersensitivity / blood,  drug therapy
Immunoglobulin E / blood,  physiology*
Methimazole / therapeutic use
Middle Aged
Pollen / immunology
Prednisone / therapeutic use
Thyroid Diseases / blood,  drug therapy,  physiopathology
Thyroid Gland / drug effects,  physiopathology
Reg. No./Substance:
0/Antithyroid Agents; 0/Glucocorticoids; 37341-29-0/Immunoglobulin E; 53-03-2/Prednisone; 60-56-0/Methimazole

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