Document Detail

The possible role of hyperhomocysteinemia on IVF outcome.
MedLine Citation:
PMID:  17763935     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.
METHOD: Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.
RESULTS: Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.
CONCLUSION: The results suggest that hyperhomocysteinemia could affect IVF outcome.
Arianna Pacchiarotti; Mohamed A Mohamed; Giulietta Micara; Antonella Linari; Daniela Tranquilli; Salomè B Espinola; Cesare Aragona
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Publication Detail:
Type:  Journal Article     Date:  2007-09-01
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  24     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-01-14     Revised Date:  2013-03-13    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459-62     Citation Subset:  IM    
Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy.
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MeSH Terms
Abortion, Spontaneous / etiology*
Embryo Implantation*
Fertilization in Vitro*
Hyperhomocysteinemia / complications*
Pregnancy Outcome
Pregnancy Rate*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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