| The possible role of human milk nucleotides as sleep inducers. | |
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MedLine Citation:
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PMID: 19178785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Breast-milk contains a potent mixture of diverse components, such as the non-protein nitrogen fraction which includes nucleotides, whose variation in levels is evident throughout lactation. In addition, these substances play an important role in sleep homeostasis. In the present study, human milk samples were analyzed using a capillary electrophoresis system. The rhythmicity of each nucleotide was studied by cosinor analysis. It was found that the nucleotides 5'AMP, 5'GMP, 5'CMP, and 5'IMP have significant (P < 0.05) circadian rhythms, the acrophases of the first two being during the night, and of the latter two during the day. While 5'UMP did not show a clear circadian rhythm, there was an increase in its levels at night. In conclusion, the rise in nocturnal levels of 5'AMP, 5'GMP, and 5'UMP could be involved in inducing the 'hypnotic' action of breast-milk at night in the infant. |
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Authors:
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Cristina L Sánchez; Javier Cubero; Javier Sánchez; Belén Chanclón; Montserrat Rivero; Ana B Rodríguez; Carmen Barriga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutritional neuroscience Volume: 12 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-30 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 2-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain. crissanchez@unex.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5'-Guanylic Acid
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analysis Adenosine Monophosphate / analysis Adult Breast Feeding Circadian Rhythm* Cytidine Monophosphate / analysis Electrophoresis, Capillary Female Humans Inosine Monophosphate / analysis Milk, Human / chemistry* Night Blindness Nucleotides / analysis*, physiology Sleep / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Nucleotides; 131-99-7/Inosine Monophosphate; 61-19-8/Adenosine Monophosphate; 63-37-6/Cytidine Monophosphate; 85-32-5/5'-Guanylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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