| The possible role of essential fatty acids in the pathophysiology of malnutrition: a review. | |
| | |
MedLine Citation:
|
PMID: 15301795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Biochemical evidence of essential fatty acid deficiency (EFAD) may exist in protein-energy malnutrition (PEM). EFAD is characterised by low 18:2omega6, often in combination with low 20:4omega6 and 22:6omega3, and high 18:1omega9 and 20:3omega9. Some PEM symptoms, notably skin changes, impaired resistance to infections, impaired growth rate and disturbed development may at least partly be explained by EFAD. One or more of the following factors could induce EFAD in PEM: low EFA intake, poor lipid digestion, absorption, transport, desaturation and increased EFA beta-oxidation and peroxidation. EFAD may perpetuate itself by decreasing lipid absorption and transport, and aggravate PEM by impairing nutrient absorption and dietary calorie utilisation. Micronutrient deficiencies may contribute to the impaired EFA bioavailability and metabolism. Nutritional rehabilitation strategies in PEM may consider adequate intakes of EFA and micronutrients, e.g. by promoting breastfeeding. More research is required to gain detailed insight into the role of EFAD in PEM. |
| | |
Authors:
|
Ella N Smit; Frits A J Muskiet; E Rudy Boersma |
Related Documents
:
|
16432355 - Serial transverse enteroplasty enhances intestinal function in a model of short bowel s... 4038985 - Protein degradation in rumen and amino acid absorption in small intestine of lactating ... 3726275 - Newborn calf intestinal absorption of immunoglobulins extracted from colostrum. 888745 - A comparison of fat absorption in young and old subjects. 18450895 - Usefulness of childhood non-high density lipoprotein cholesterol levels versus other li... 19912045 - Effects of dietary lysine supplementation on upper respiratory and ocular disease and d... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 71 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2004 Oct |
Date Detail:
|
Created Date: 2004-08-10 Completed Date: 2005-01-28 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
|
Languages: eng Pagination: 241-50 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Laboratory Medicine, c/o Prof. Dr. Frits A.J. Muskiet, CMC-V, Y1.147, Groningen University Hospital, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. ella.smit@undp.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Fatty Acids, Essential / deficiency, metabolism*, pharmacology Humans Malnutrition / metabolism, physiopathology* Oxidation-Reduction Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Essential; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male mon...
Next Document: Potency of arachidonic acid in polyunsaturated fatty acid-induced death of human monocyte-macrophage...