Document Detail

The possible role of endothelial cells in hypertensive disorders during pregnancy.
MedLine Citation:
PMID:  1635736     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify the role of endothelial cells in pregnancy-related hypertensive disorders, we studied the cytotoxic effect of sera from normal pregnant women and from gravidas with various hypertensive complications of pregnancy. METHODS: We obtained serum samples from 84 Japanese women: 17 with preeclampsia, ten with gestational hypertension, six with chronic hypertension, five with chronic hypertension with superimposed preeclampsia, 21 normal gravidas, and 25 healthy nonpregnant women. Endothelial cell injury was measured by the release of radiolabeled chromium from the cells into the culture medium. RESULTS: The mean (+/- standard error of the mean) values of chromium 51 release in preeclampsia, gestational hypertension, chronic hypertension, chronic hypertension with superimposed preeclampsia, normal pregnancy, and healthy nonpregnant women were: 21.9 +/- 2.1, 10.0 +/- 2.0, 9.2 +/- 2.3, 12.9 +/- 0.8, 8.4 +/- 1.4, and 7.3 +/- 1.6%, respectively. Normal pregnant and nonpregnant subjects did not differ with respect to endothelial cell injury. Sera from women with preeclampsia demonstrated significantly greater endothelial cell injury than did sera from normal gravidas. Subjects with the three other categories of hypertensive disorders did not differ significantly from normal gravidas. CONCLUSION: Preeclampsia is characterized by the presence of a serum factor cytotoxic to endothelial cells. Therefore, the mechanism responsible for the increase in blood pressure differs between women with preeclampsia and those with other hypertensive disorders in pregnancy.
K Tsukimori; H Maeda; M Shingu; T Koyanagi; M Nobunaga; H Nakano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  80     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Beppu, Japan.
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MeSH Terms
Cells, Cultured
Chromium Radioisotopes
Chronic Disease
Endothelium, Vascular / physiopathology*
Hypertension / blood,  physiopathology*
Pre-Eclampsia / blood,  physiopathology*
Pregnancy Complications, Cardiovascular / blood,  physiopathology*
Umbilical Veins
Reg. No./Substance:
0/Chromium Radioisotopes

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