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The possible role of cell cycle stage in mammalian cloning.
MedLine Citation:
PMID:  14564050     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Progress in mammalian cloning started from cloning embryos (of mice, rats, rabbits, sheep, goats, pigs, cattle and rhesus monkeys) and culminated in obtaining clones of sheep, cattle, pigs and mice from adult somatic cells. Knowing the relationship between the cell cycles of the recipient and the donor of cell nucleus in embryonic cloning by nuclear transfer one can adjust the phases of the cell cycle properly. Metaphase II recipients accept G1 (in most species) or G2 donors (in the mouse). Interphase recipients can harbour nuclei in all stages of cell cycle. Relatively little is known about somatic cloning. Two attitudes are applied: either the donor is in the G0 phase or the recipient is in a prolonged MII phase.
Authors:
J A Modliński; J Grabarek; B Płusa; J Karasiewicz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied genetics     Volume:  42     ISSN:  1234-1983     ISO Abbreviation:  J. Appl. Genet.     Publication Date:  2001  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2004-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9514582     Medline TA:  J Appl Genet     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  153-76     Citation Subset:  -    
Affiliation:
Department of Experimental Embryology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Wólka Kosowska, Poland.
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