Document Detail

A possible role for the PPARG Pro12Ala polymorphism in preterm birth.
MedLine Citation:
PMID:  17259396     Owner:  NLM     Status:  MEDLINE    
The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene could play a role in birth weight and duration of gestation. We genotyped two independent cross-sectional studies from Northern Ireland (n = 382 and 620). In combined populations, the PPARG Ala12 allele was associated (P = 0.03) with lower birth weight, primarily caused by shorter gestational duration (P = 0.04). The frequency of Ala12 allele carriers was higher (P = 0.027) in the group of individuals born before term (35%, n = 60) than in the group of individuals born at term (22%, n = 942). The odds ratios (95% CI) of preterm birth for Ala12 allele carriers were 1.9 (1.1-3.4), P = 0.022, and 4.2 (1.9-9.7), P = 0.0006 (adjusted for sex, maternal age, and study), when considering 37 or 35 weeks of pregnancy as a threshold for preterm birth, respectively. Interestingly, the same allele was also associated with a moderate decreased risk of miscarriages in mothers. In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.
Aline Meirhaeghe; Colin A G Boreham; Liam J Murray; Florence Richard; George Davey Smith; Ian S Young; Philippe Amouyel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes     Volume:  56     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-04-09     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  AIM; IM    
INSERM U744, Institut Pasteur de Lille, Université de Lille, 1 rue du Pr. Calmette, BP 245, 59019 Lille Cedex, France.
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MeSH Terms
Birth Weight / genetics*
Cohort Studies
Genetic Predisposition to Disease*
Gestational Age
Metabolic Diseases / genetics*
Northern Ireland
PPAR gamma / genetics*
Polymorphism, Genetic*
Premature Birth / genetics*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/PPAR gamma

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