Document Detail


On the possible pharmacological role of UDP-glucose on some muscular metabolites.
MedLine Citation:
PMID:  6714417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intraperitoneal administration of UDP-glucose were studied on male rat gastrocnemius muscle. Muscular glycolytic substrates and metabolites (glycogen, glucose, glucose-6-phosphate, pyruvate, lactate), Krebs' cycle intermediates (citrate, alpha-ketoglutarate, malate), related aminoacids (glutamate, alanine), ammonia, energy store and mediators (creatine phosphate, ATP, ADP, AMP) and the energy charge potential were evaluated. UDP-glucose was administered intraperitoneally at doses of 0.8, 2.0 and 5.0 mg/kg daily for 1, 2 and 4 weeks. The influence of the factors: "dose" of UDP-glucose and "time-course" of treatment was defined. After two weeks, the administration of the three doses tested of UDP-glucose changed the muscular concentration of few glycolytic metabolites, and of some Krebs' cycle intermediates, while after 1 or 4 weeks of treatment there was negligible response.
Authors:
O Pastoris; M Dossena; L Vercesi; C Migliavacca; M Taglietti; G Benzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  39     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-19     Completed Date:  1984-06-19     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  246-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaerobiosis
Animals
Energy Metabolism / drug effects
Glycolysis / drug effects
Hydrolysis
Male
Muscles / drug effects,  metabolism*
Rats
Rats, Inbred Strains
Time Factors
Uridine Diphosphate Glucose / pharmacology,  physiology*
Uridine Diphosphate Sugars / physiology*
Chemical
Reg. No./Substance:
0/Uridine Diphosphate Sugars; 133-89-1/Uridine Diphosphate Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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