| On the possible pharmacological role of UDP-glucose on some muscular metabolites. | |
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MedLine Citation:
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PMID: 6714417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of intraperitoneal administration of UDP-glucose were studied on male rat gastrocnemius muscle. Muscular glycolytic substrates and metabolites (glycogen, glucose, glucose-6-phosphate, pyruvate, lactate), Krebs' cycle intermediates (citrate, alpha-ketoglutarate, malate), related aminoacids (glutamate, alanine), ammonia, energy store and mediators (creatine phosphate, ATP, ADP, AMP) and the energy charge potential were evaluated. UDP-glucose was administered intraperitoneally at doses of 0.8, 2.0 and 5.0 mg/kg daily for 1, 2 and 4 weeks. The influence of the factors: "dose" of UDP-glucose and "time-course" of treatment was defined. After two weeks, the administration of the three doses tested of UDP-glucose changed the muscular concentration of few glycolytic metabolites, and of some Krebs' cycle intermediates, while after 1 or 4 weeks of treatment there was negligible response. |
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Authors:
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O Pastoris; M Dossena; L Vercesi; C Migliavacca; M Taglietti; G Benzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Il Farmaco; edizione scientifica Volume: 39 ISSN: 0430-0920 ISO Abbreviation: Farmaco Sci Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-06-19 Completed Date: 1984-06-19 Revised Date: 2009-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0370716 Medline TA: Farmaco Sci Country: ITALY |
Other Details:
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Languages: eng Pagination: 246-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobiosis Animals Energy Metabolism / drug effects Glycolysis / drug effects Hydrolysis Male Muscles / drug effects, metabolism* Rats Rats, Inbred Strains Time Factors Uridine Diphosphate Glucose / pharmacology, physiology* Uridine Diphosphate Sugars / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Uridine Diphosphate Sugars; 133-89-1/Uridine Diphosphate Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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