Document Detail


A possible new reflex pathway for micturition after spinal cord injury.
MedLine Citation:
PMID:  8058346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to restore bladder function after spinal cord injury, a controllable new reflex pathway has been established in rats. It involves a somatic reflex arc with an artificially modified efferent branch which passes the somatic motor impulses to the bladder. This is achieved by intradural microanastomosis of the left L4 ventral root to L6 ventral root, while leaving the L4 dorsal root intact as a starter of micturition. The 'skin-CNS-bladder' reflex pathway is designed to initiate voiding by scratching the skin. After axonal regeneration, 15 of the 24 rats with the new pathway underwent electrophysiological study. Single stimuli (0.3-3 mA, 0.02-0.2 ms duration) to the left L4 nerve resulted in evoked potentials (0.5-1 mV) recorded from the left L6 nerve distal to the anastomosis. The bladder detrusor contraction was very quickly initiated by trains of the stimuli and bladder pressures increased rapidly to levels similar to controls. Neural tracing study with horseradish peroxidase (HRP) on six rats with the pathway demonstrated that the somatic motor axons regenerated successfully into the pelvic nerve, and the bladder was reinnervated by the L4 somatic motor neurons. The bladder contraction can also be initiated by electrostimulation of left sciatic nerve as well as scratching the L4 related skin. A new concept may be derived from the skin-CNS-bladder reflex pathway: the impulses delivered from the efferent neurons of a somatic reflex arc can be transferred to initiate responses of an autonomic effector.
Authors:
C G Xiao; C J Godec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paraplegia     Volume:  32     ISSN:  0031-1758     ISO Abbreviation:  Paraplegia     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985038R     Medline TA:  Paraplegia     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  300-7     Citation Subset:  IM    
Affiliation:
Department of Urology, Long Island College Hospital, SUNY Health Science Center at Brooklyn 11201.
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical
Animals
Electrophysiology
Evoked Potentials / physiology
Histocytochemistry
Horseradish Peroxidase
Male
Nerve Regeneration
Neural Pathways / physiology,  surgery
Rats
Rats, Sprague-Dawley
Reflex / physiology*
Skin / innervation,  surgery
Skin Physiological Phenomena
Spinal Cord Injuries / complications*
Urinary Bladder / innervation,  physiology,  surgery*
Urination Disorders / etiology,  surgery*
Chemical
Reg. No./Substance:
EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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