Document Detail


A possible link between BDNF and mTOR in control of food intake.
MedLine Citation:
PMID:  25309497     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Food intake is intricately regulated by glucose, amino acids, hormones, neuropeptides, and trophic factors through a neural circuit in the hypothalamus. Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor in the brain, regulates differentiation, maturation, and synaptic plasticity throughout life. Among its many roles, BDNF exerts an anorexigenic function in the brain. However, the intracellular signaling induced by BDNF to control food intake is not fully understood. One candidate for the molecule involved in transducing the anorexigenic activity of BDNF is the mammalian target of rapamycin (mTOR). mTOR senses extracellular amino acids, glucose, growth factors, and neurotransmitters, and regulates anabolic reactions response to these signals. Activated mTOR increases protein and lipid synthesis and inhibits protein degradation. In the hypothalamus, mTOR activation is thought to reduce food intake. Here we summarize recent findings regarding BDNF- and mTOR-mediated feeding control, and propose a link between these molecules in eating behavior.
Authors:
Nobuyuki Takei; Kazuo Furukawa; Osamu Hanyu; Hirohito Sone; Hiroyuki Nawa
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Publication Detail:
Type:  Journal Article; Review     Date:  2014-09-25
Journal Detail:
Title:  Frontiers in psychology     Volume:  5     ISSN:  1664-1078     ISO Abbreviation:  Front Psychol     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-13     Completed Date:  2014-10-13     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  101550902     Medline TA:  Front Psychol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1093     Citation Subset:  -    
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