Document Detail


A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken.
MedLine Citation:
PMID:  8764834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Extended black (E) locus on chromosome 1 acts within the melanocyte to regulate feather color pigmentation in the chicken. Several alleles exhibiting different pigmentation have been described and their phenotypes are similar to those of the murine extension locus which encodes melanocortin 1-receptor (MC1-R), the receptor for alpha-melanocyte-stimulating hormone (alpha-MSH). To investigate whether the MC1-R gene is responsible for E-locus function, we examined the structure of MC1-R in E-locus mutants by RFLP analysis and genomic DNA sequencing. In the most recessive allele (ey), which exhibits a uniformly red-yellow pigmentation, MC1-R was found to contain amino acid substitutions possibly causing functional deficiency. On the other hand, in the most dominant allele (E), which confers a uniformly black pigmentation, MC1-R possessed mutation responsible for a constitutively active MC1-R and resultant black coat color in mice. Our finding that the structure of MC1-R was affected by individual E-locus alleles strongly suggests that MC1-R is associated with the E-locus. Furthermore, since the same mutation of MC1-R was found in mice and chickens that exhibit the same pigmentation, it is possible that the regulatory mechanism of MC1-R function is shared in chickens and mammals.
Authors:
S Takeuchi; H Suzuki; M Yabuuchi; S Takahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1308     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  164-8     Citation Subset:  IM    
Affiliation:
Department of Biology, Faculty of Science, Okayama University, Japan. stakeuch@cc.okayama.u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Sequence
Animals
Base Sequence
Chick Embryo
Feathers / physiology*
Genes, Recessive
Molecular Sequence Data
Mutation
Pigmentation / physiology*
Polymorphism, Restriction Fragment Length
Receptors, Corticotropin / genetics*
Receptors, Melanocortin
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/Receptors, Corticotropin; 0/Receptors, Melanocortin

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