Document Detail

The possible influence of the menstrual cycle on the adherence of Candida albicans to human buccal epithelial cells in vitro.
MedLine Citation:
PMID:  8517807     Owner:  NLM     Status:  MEDLINE    
Although the influence of the menstrual cycle on both vaginal candidosis and Candida albicans adherence to vaginal epithelial cells in vitro has been shown to be significant, similar studies have not been made on oral candidosis and adherence to buccal epithelial cells. The aim of this study was therefore to use an in vitro adherence assay to investigate the possible influence of the menstrual cycle on the adherence of C. albicans to buccal epithelial cells. Epithelial cells were collected from a single, healthy, female volunteer on days 5, 15, 22 and 28 of six menstrual cycles. Adherence of C. albicans was significantly higher to buccal epithelial cells collected on day 5 of the menstrual cycle when compared with days 15, 22 and 28, both in terms of the percentage of buccal epithelial cells with adherent C. albicans and the number of C. albicans adhering per 200 buccal epithelial cells in four out of six menstrual cycles (p < 0.001). This result indicates that hormonal influences should be considered when buccal epithelial cells are used in vitro to assess candidal adherence and may implicate hormonal factors in the aetiology of oral candidosis.
E D Theaker; D B Drucker; A C Gibbs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  38     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-5     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Medicine, Manchester, U.K.
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MeSH Terms
Bacterial Adhesion*
Candida albicans / physiology*
Candidiasis, Oral / physiopathology
Epithelial Cells
Epithelium / microbiology
Gonadal Steroid Hormones / physiology
Menstrual Cycle*
Mouth Mucosa / cytology,  microbiology*
Time Factors
Reg. No./Substance:
0/Gonadal Steroid Hormones

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