Document Detail


The possible etiopathogenic genes of Sjögren's syndrome.
MedLine Citation:
PMID:  16137615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sjögren's syndrome is a chronic autoimmune disease characterized by focal lymphocytic infiltration of lacrimal and salivary glands, but the precise mechanism of this syndrome is unclear. To clarify the pathogenesis of Sjögren's syndrome, the related genes must be identified. In the present study, we investigate the increased expression of genes and molecules related to Sjögren's syndrome and present our findings of cDNA microarray analysis in the mouse model. Furthermore, we present the results of immunohistochemical analysis of salivary glands in the mouse model and patients with Sjögren's syndrome. This approach might open a new discussion of the existence of principal pathogenic molecules in Sjögren's syndrome.
Authors:
Masami Takei; Hidetaka Shiraiwa; Takashi Azuma; Yoshio Hayashi; Naoyuki Seki; Shigemasa Sawada
Related Documents :
2327235 - Nervous system manifestations in sjögren's syndrome.
18827415 - An autopsy case of sjögren's syndrome with acute encephalomyelopathy.
25197115 - Anaesthesia for emergency ventriculo-peritoneal shunt in an adolescent with noonan's sy...
18431095 - Secondary cutaneous nodular aa amyloidosis in a patient with primary sjögren syndrome ...
10599395 - Naevus varicosus osteohypertrophicus. an early diagnostic approach.
16842135 - Dyslipidaemia, hypercoagulability and the metabolic syndrome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autoimmunity reviews     Volume:  4     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-02     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Hematology and Rheumatology, Nihon University, School of Medicine, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Disease Progression
Gene Expression Profiling*
Humans
Mice
Mice, Inbred MRL lpr
Oligonucleotide Array Sequence Analysis
Salivary Glands / immunology,  metabolism
Sjogren's Syndrome / etiology*,  genetics*,  immunology
Up-Regulation / genetics,  immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunoglobulin G from anti-glucose-6-phosphate isomerase antibodies positive patient with rheumatoid...
Next Document:  Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by ext...