| The possible etiopathogenic genes of Sjögren's syndrome. | |
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MedLine Citation:
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PMID: 16137615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sjögren's syndrome is a chronic autoimmune disease characterized by focal lymphocytic infiltration of lacrimal and salivary glands, but the precise mechanism of this syndrome is unclear. To clarify the pathogenesis of Sjögren's syndrome, the related genes must be identified. In the present study, we investigate the increased expression of genes and molecules related to Sjögren's syndrome and present our findings of cDNA microarray analysis in the mouse model. Furthermore, we present the results of immunohistochemical analysis of salivary glands in the mouse model and patients with Sjögren's syndrome. This approach might open a new discussion of the existence of principal pathogenic molecules in Sjögren's syndrome. |
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Authors:
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Masami Takei; Hidetaka Shiraiwa; Takashi Azuma; Yoshio Hayashi; Naoyuki Seki; Shigemasa Sawada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Autoimmunity reviews Volume: 4 ISSN: 1568-9972 ISO Abbreviation: Autoimmun Rev Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-02 Completed Date: 2008-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 479-84 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Hematology and Rheumatology, Nihon University, School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Disease Progression Gene Expression Profiling* Humans Mice Mice, Inbred MRL lpr Oligonucleotide Array Sequence Analysis Salivary Glands / immunology, metabolism Sjogren's Syndrome / etiology*, genetics*, immunology Up-Regulation / genetics, immunology |
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