Document Detail

The possible etiopathogenic genes of Sjögren's syndrome.
MedLine Citation:
PMID:  16137615     Owner:  NLM     Status:  MEDLINE    
Sjögren's syndrome is a chronic autoimmune disease characterized by focal lymphocytic infiltration of lacrimal and salivary glands, but the precise mechanism of this syndrome is unclear. To clarify the pathogenesis of Sjögren's syndrome, the related genes must be identified. In the present study, we investigate the increased expression of genes and molecules related to Sjögren's syndrome and present our findings of cDNA microarray analysis in the mouse model. Furthermore, we present the results of immunohistochemical analysis of salivary glands in the mouse model and patients with Sjögren's syndrome. This approach might open a new discussion of the existence of principal pathogenic molecules in Sjögren's syndrome.
Masami Takei; Hidetaka Shiraiwa; Takashi Azuma; Yoshio Hayashi; Naoyuki Seki; Shigemasa Sawada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autoimmunity reviews     Volume:  4     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-02     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Department of Internal Medicine, Division of Hematology and Rheumatology, Nihon University, School of Medicine, Tokyo, Japan.
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MeSH Terms
Disease Models, Animal
Disease Progression
Gene Expression Profiling*
Mice, Inbred MRL lpr
Oligonucleotide Array Sequence Analysis
Salivary Glands / immunology,  metabolism
Sjogren's Syndrome / etiology*,  genetics*,  immunology
Up-Regulation / genetics,  immunology

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