Document Detail

A possible effect of amisulpride on a prolactinoma growth in a woman with borderline personality disorder.
MedLine Citation:
PMID:  15225684     Owner:  NLM     Status:  MEDLINE    
The authors report the case of a woman with borderline personality disorder who developed a prolactinoma probably induced by amisulpride. This patient was treated with 300 mg of amisulpride per day for a delirium. Her brain MRI was normal. Four months later this patient developed a micro-adenoma (5mm) on the right side of the pituitary gland with amenorrhea and galactorrhea. Amisulpride treatment was withdrawn and replaced by a treatment of quetiapine 100 mg day(-1). The hyperprolactinemia symptoms disappeared. This report shows that the short-term use of amisulpride treatment was linked to an elevation in the PRL level with a possible induction of a pituitary adenoma.
Nader Perroud; Philippe Huguelet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  50     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2005-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-9     Citation Subset:  IM    
Département de Psychiatrie, Hôpitaux Universitaires de Genève, 36, Rue du XXXI Décembre, 1207 Geneva, Switzerland.
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MeSH Terms
Borderline Personality Disorder / blood,  drug therapy*
Pituitary Neoplasms / blood,  chemically induced*
Prolactin / blood
Prolactinoma / blood,  chemically induced*
Sulpiride / adverse effects*,  analogs & derivatives*
Reg. No./Substance:
15676-16-1/Sulpiride; 53583-79-2/sultopride; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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