Document Detail

A possible drug interaction between rifampicin and enalapril.
MedLine Citation:
PMID:  2848708     Owner:  NLM     Status:  MEDLINE    
When a 35-year-old man with essential hypertension was treated with antibiotics for brucellosis his blood pressure rose significantly. While all other treatment was kept constant rifampicin was discontinued. On rechallenge rifampicin did not alter serum concentrations of enalapril or the area under the curve (AUC) between 0 and 7 h, but it did reduce the AUC of the active metabolite enalaprilat by 31%. These observations suggest that there may be an interaction between rifampicin and enalapril, causing reduced hypotensive efficacy of enalapril. The mechanism of such an interaction merits further study, but it could be due to enhanced renal clearance of enalaprilat.
D Kandiah; W J Penny; A G Fraser; M J Lewis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  35     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  431-2     Citation Subset:  IM    
Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
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MeSH Terms
Blood Pressure / drug effects
Brucellosis / complications,  drug therapy
Drug Interactions
Enalapril / analogs & derivatives*,  antagonists & inhibitors*,  blood,  therapeutic use
Hypertension / blood,  complications,  drug therapy*
Rifampin / adverse effects*,  therapeutic use
Time Factors
Reg. No./Substance:
13292-46-1/Rifampin; 75847-73-3/Enalapril; 84680-54-6/Enalaprilat

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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