| A possible drug interaction between rifampicin and enalapril. | |
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MedLine Citation:
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PMID: 2848708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When a 35-year-old man with essential hypertension was treated with antibiotics for brucellosis his blood pressure rose significantly. While all other treatment was kept constant rifampicin was discontinued. On rechallenge rifampicin did not alter serum concentrations of enalapril or the area under the curve (AUC) between 0 and 7 h, but it did reduce the AUC of the active metabolite enalaprilat by 31%. These observations suggest that there may be an interaction between rifampicin and enalapril, causing reduced hypotensive efficacy of enalapril. The mechanism of such an interaction merits further study, but it could be due to enhanced renal clearance of enalaprilat. |
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Authors:
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D Kandiah; W J Penny; A G Fraser; M J Lewis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 35 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 431-2 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Brucellosis / complications, drug therapy Drug Interactions Enalapril / analogs & derivatives*, antagonists & inhibitors*, blood, therapeutic use Enalaprilat Humans Hypertension / blood, complications, drug therapy* Male Rifampin / adverse effects*, therapeutic use Time Factors |
| Chemical | |
Reg. No./Substance:
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13292-46-1/Rifampin; 75847-73-3/Enalapril; 84680-54-6/Enalaprilat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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