Document Detail

A possible cause of non-disjunction of additional chromosome 21 in Down syndrome.
MedLine Citation:
PMID:  2940437     Owner:  NLM     Status:  MEDLINE    
A possible cause of non-disjunction of chromosome 21 in Down Syndromes has been cytogenetically evaluated by examining the parents by Ag-staining technique. In all the cases studied so far, the contributing parents have active ribosomal cistrons on both chromosomes 21 i.e. both chromosomes are stained positively by silver staining. These results show that the active NORs might play an essential role in meiotic non-disjunction. Furthermore, the preliminary results demonstrate that the acrocentric associations of homologous and non-homologous nature involving chromosome 21 are the most frequent in the contributing parent which may further indicate the role of multiple cellular factors affecting the associations in promoting the nondisjunction in addition to active NORs. The possible mechanisms regarding the non-disjunction of chromosome 21 have been described.
R S Verma; A Babu; S Chemitiganti; H Dosik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  202     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  339-41     Citation Subset:  IM    
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MeSH Terms
Chromosomes, Human, 21-22 and Y*
Down Syndrome / genetics*
Nondisjunction, Genetic*

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