Document Detail

The possibility of passive transport of histamine through biological membranes.
MedLine Citation:
PMID:  550906     Owner:  NLM     Status:  MEDLINE    
The possibility of transport of free and heparin-bound histamine along the concentration gradient through bimolecular lipid membranes (BLM) and the influence of various factors on it was studied. It was shown that histamine is capable of diffusing through BLM in the form of a singly charged cation. In contrast to histamine, neither heparin nor the histamine-heparin complex (HsHC) penetrates through BLM. It was established that the action of histamine-liberating factors -- increasing the ionic strength to 0.15 and the addition of trypsin to the solution -- on HsHC leads to the appearance of transport of histamine through the BLM as a result of an increase in the concentration of free histamine in solution.
K L Erzinkyan; M M Katz; S V Nizhnii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology bulletin of the Academy of Sciences of the USSR     Volume:  6     ISSN:  0098-2164     ISO Abbreviation:  Biol Bull Acad Sci USSR     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7513560     Medline TA:  Biol Bull Acad Sci USSR     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Heparin / pharmacology
Histamine / physiology*
Lipid Bilayers
Membrane Lipids / physiology*
Tolonium Chloride / pharmacology
Reg. No./Substance:
0/Lipid Bilayers; 0/Membrane Lipids; 51-45-6/Histamine; 9005-49-6/Heparin; 92-31-9/Tolonium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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