Document Detail


A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo.
MedLine Citation:
PMID:  11585808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positional information in the dorsoventral axis of the Drosophila embryo is encoded by a BMP activity gradient formed by synergistic signaling between the BMP family members Decapentaplegic (DPP) and Screw (SCW). short gastrulation (sog), which is functionally homologous to Xenopus Chordin, is expressed in the ventrolateral regions of the embryo and has been shown to act as a local antagonist of BMP signaling. Here we demonstrate that SOG has a second function, which is to promote BMP signaling on the dorsal side of the embryo. We show that a weak, homozygous-viable sog mutant is enhanced to lethality by reduction in the activities of the Smad family members Mad or Medea, and that the lethality is caused by defects in the molecular specification and subsequent cellular differentiation of the dorsal-most cell type, the amnioserosa. While previous data had suggested that the negative function of SOG is directed against SCW, we present data that suggests that the positive activity of SOG is directed towards DPP. We demonstrate that Chordin shares the same apparent ligand specificity as does SOG, preferentially inhibiting SCW but not DPP activity. However, in Drosophila assays Chordin does not have the same capacity to elevate BMP signaling as does SOG, identifying a functional difference in the otherwise well conserved process of dorsoventral pattern formation in arthropods and chordates.
Authors:
E Decotto; E L Ferguson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  128     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-04     Completed Date:  2001-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3831-41     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology*
Bone Morphogenetic Proteins / genetics,  metabolism*
DNA-Binding Proteins / genetics,  metabolism
Drosophila / embryology*
Drosophila Proteins / genetics,  metabolism
Embryo, Nonmammalian / metabolism
Female
Fetal Death
Gastrula
Gene Dosage
Gene Expression Regulation, Developmental
Glycoproteins*
Homeodomain Proteins / genetics,  metabolism
Insect Proteins / genetics,  metabolism*
Intercellular Signaling Peptides and Proteins*
Male
Mutation
Proteins / genetics,  metabolism
Repressor Proteins / genetics,  metabolism
Signal Transduction
Smad4 Protein
Trans-Activators / genetics,  metabolism
Transcription Factors*
Transforming Growth Factor beta / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
GM 50838/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Glycoproteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/MAD protein, Drosophila; 0/Medea protein, Drosophila; 0/Proteins; 0/Repressor Proteins; 0/Smad4 Protein; 0/TSG protein, Drosophila; 0/Trans-Activators; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/Zen protein, Drosophila; 0/dpp protein, Drosophila; 0/screw protein, Drosophila; 0/sog protein, Drosophila; 93586-27-7/chordin

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