Document Detail


A porcine model of sepsis resulting from the combined insults of hemorrhage and peritonitis.
MedLine Citation:
PMID:  10774618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological responses to either hemorrhage or sepsis have been well documented, however, their simultaneous delivery, as often seen in penetrating trauma, has not been extensively studied. A terminally-anesthetized porcine model of fixed-volume hemorrhage combined with intraperitoneal sepsis was developed. Large White pigs (45-60 kg) were bled 40% of blood volume and peritonitis was induced using an E. coil (O18:K1:H7) culture. Three groups of animals were sequentially studied. Group A (n = 8) received 10(8) bacteria, and Groups B (n = 4) and C (n = 5) received 10(10) organisms. All animals were maintained on a 2.5 mL/kg/h infusion of 0.9% saline. Group C was autotransfused at 1 h. Animals were monitored for up to 24 h. Cardiovascular features of hypovolemia were recorded in all animals. Animals in Group A improved clinically with little microbiological evidence of systemic sepsis. Group B showed rapid cardiovascular collapse, early E. coil-positive blood cultures, and an early rise in serum TNF-alpha levels. Autotransfusion of Group C significantly improved cardiopulmonary parameters, acid-base status, and survival. A reproducible model of hemorrhage and peritonitis, appropriate for abdominal trauma, which allows investigation of resuscitative and pharmacological interventions has been characterized.
Authors:
S J Parker; P F Hill; D Brown; C E Kenward; P E Watkins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  13     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2000  
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Affiliation:
Biomedical Sciences, DERA Porton Down, Salisbury, Wiltshire, UK.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Animals
Blood Pressure
Blood Transfusion, Autologous
Blood Volume
Endotoxins / blood
Escherichia coli Infections / complications*
Female
Hemodynamics*
Hemorrhage / blood,  complications*,  physiopathology
Inflammation
Peritonitis / blood,  complications*,  physiopathology
Pulmonary Circulation
Sepsis / etiology,  physiopathology*
Survival Analysis
Swine
Tumor Necrosis Factor-alpha / analysis
Vascular Resistance
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Tumor Necrosis Factor-alpha

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