Document Detail

A porcine model of full-thickness burn, excision and skin autografting.
MedLine Citation:
PMID:  18617332     Owner:  NLM     Status:  MEDLINE    
Acute burn wounds often require early excision and adequate coverage to prevent further hypothermia, protein and fluid losses, and the risk of infection. Meshed autologous skin grafts are generally regarded as the standard treatment for extensive full-thickness burns. Graft take and rate of wound healing, however, depend on several endogenous factors. This paper describes a standardized reproducible porcine model of burn and skin grafting which can be used to study the effects of topical treatments on graft take and re-epithelialization. Procedures provide a protocol for successful porcine burn wound experiments with special focus on pre-operative care, anesthesia, burn allocation, excision and grafting, postoperative treatment, dressing application, and specimen collection. Selected outcome measurements include percent area of wound closure by planimetry, wound assessment using a clinical assessment scale, and histological scoring. The use of this standardized model provides burn researchers with a valuable tool for the comparison of different topical drug treatments and dressing materials in a setting that closely mimics clinical reality.
Ludwik K Branski; Rainer Mittermayr; David N Herndon; William B Norbury; Oscar E Masters; Martina Hofmann; Daniel L Traber; Heinz Redl; Marc G Jeschke
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-10
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  34     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-06-09     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1119-27     Citation Subset:  IM    
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MeSH Terms
Burns / pathology,  surgery*
Disease Models, Animal*
Graft Survival
Skin / injuries*
Skin Transplantation / methods*
Surgical Mesh
Treatment Outcome
Wound Healing / physiology*
Grant Support
R01 GM056687/GM/NIGMS NIH HHS; R01 GM056687-08/GM/NIGMS NIH HHS; T32 GM008256/GM/NIGMS NIH HHS; T32 GM008256-18/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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